Novel inflammatory metabolic parameters as predictors of metabolic dysfunction-associated fatty liver disease in people living with HIV receiving antiretroviral therapy: a retrospective cohort study

In this large cohort of PLWH on ART, LHR and PHR were independent predictors of incident MAFLD, with LHR demonstrating the strongest and most consistent predictive value. AISI was not associated with MAFLD. LHR and PHR, as simple, low-cost indices derived from routine laboratory tests, may serve as practical tools for identifying high-risk individuals who could benefit from early monitoring and targeted intervention.