Aspersorbiciols A and B, Two Hybrid Sorbicillinoids with an Undescribed Skeleton from a Marine-Derived Fungus <i>Aspergillus</i> sp. GXIMD02072
Aspersorbiciols A and B, two hybrid sorbicillinoids, were obtained from marine fungus <i>Aspergillus</i> sp. GXIMD02072. Their structures were elucidated by spectroscopic analyses, quantum chemical calculations, and X-ray diffraction. Structurally, aspersorbiciols A and B represented the first reported instances of sorbicillinoids incorporating a 2,6-dioxa-pentacyclo-[10.4.0.0<sup>4,8</sup>.0<sup>4,16</sup>.0<sup>8,13</sup>]-hexadecane cage-like skeleton. Aspersorbiciols A and B suppressed lipopolysaccharide-induced NF-κB luciferase activities and the receptor activator of NF-κB ligand-induced osteoclastogenesis.
Authors
- Zhen Li (ORCID: https://orcid.org/0000-0002-8853-4941)
- Pei Cao (ORCID: https://orcid.org/0000-0002-2298-4667)
- Yanhui Tan
- Quan Teng
- Yonghong Liu
- Xuelian Qin
- Binghua Li
- Chenghai Gao
Institutions
- Hunan University (CN)
- Guangxi Normal University (CN)
- Guangxi University of Chinese Medicine (CN)
- United States Marine Corps (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1021/acs.orglett.5c04786
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00