Editorial: Advancements in therapeutic strategies for skeletal muscle and cardiovascular diseases: integrating innovative approaches for enhanced outcomes

Advancements in therapeutic strategies for skeletal muscle and cardiovascular diseases: integrating innovative approaches for enhanced outcomes Skeletal muscle disorders and cardiovascular diseases remain leading causes of disability and mortality worldwide, affecting individuals across diverse populations.Despite significant advances in conventional pharmacological, surgical, and rehabilitation-based approaches, many patients continue to face incomplete recovery, disease progression, or long-term functional impairment.These limitations reflect the biological complexity of muscle and cardiovascular tissues and highlight the need for therapeutic strategies that extend beyond symptom control toward restoring or reprogramming diseased cells, aligning with the emerging field of regenerative pharmacology and advanced therapeutic medicinal products.In this context, cell and gene therapies are reshaping the therapeutic landscape.Recent regulatory approvals of advanced therapy products mark a critical inflection point, demonstrating that these approaches can be successfully translated from experimental platforms into clinically validated interventions.Collectively, this momentum supports a shift toward more durable, mechanism-driven treatments and sets the stage for new opportunities to improve outcomes in skeletal muscle and cardiovascular disease.This Frontiers Research Topic, entitled "Advancements in Therapeutic Strategies for Skeletal Muscle and Cardiovascular Diseases: Integrating Innovative Approaches for Enhanced Outcomes," consolidates original research and comprehensive review articles that demonstrate how progress in cell and gene therapy is increasingly propelled by a deeper understanding of tissue microenvironments, molecular mechanisms, and pioneering therapeutic platforms.Although the studies target different organs and disease contexts, they share a common