Integrated network pharmacology and experimental verification to reveal the mechanisms of curcumin in the treatment of colorectal cancer
This study comprehensively elucidates the molecular mechanisms by which curcumin exerts its therapeutic effects in CRC via modulation of ferroptosis and Wnt/β-catenin signaling pathway. These findings provide novel mechanistic insights and support the translational potential of curcumin in preclinical and clinical frameworks.
Authors
- Huimou Chen
- Fuheng Liu
- Canfeng Cai
- Zhilong Yuan (ORCID: https://orcid.org/0009-0004-1767-6696)
- Jing Hu
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fphar.2025.1703562
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province