Beyond surface dose: subcutaneous dose escalation underlies TomoTherapy’s skin toxicity in breast radiotherapy
The heightened skin toxicity with TOMO is not predicted by conventional skin surface dose metrics but is explained by a significant dose escalation within the subcutaneous P-PAST region. Plan evaluation for TOMO should incorporate volumetric dose assessment of the dermal compartment to mitigate toxicity.
Authors
- Wenjun Zhao (ORCID: https://orcid.org/0000-0002-8579-3155)
- Chenchen Wu (ORCID: https://orcid.org/0000-0002-2489-7532)
- Jiao Xue
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fonc.2026.1760716
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China