A monocyte-derived blood transcriptomic signature reveals systemic immunosuppression in HCC and partial reversal following curative therapy
Early-stage HCC induces a reversible, systemic immunosuppressive transcriptome captured by a monocyte-derived 23-gene blood signature; tumor removal partially restores this profile within three months. These results highlight the potential of blood-derived monocyte signatures as noninvasive biomarkers of HCC-associated immunosuppression and clinical outcome.
Authors
- T Wirth
- Ahmed Alaswad (ORCID: https://orcid.org/0000-0003-1770-1332)
- Bibiana Costa
- Cheng‐Jian Xu (ORCID: https://orcid.org/0000-0003-1586-4672)
- Dominik A. Machtens (ORCID: https://orcid.org/0000-0002-1597-7901)
- Aditi Kumthekar
- Yang Li (ORCID: https://orcid.org/0000-0001-6743-4004)
- Yuesi Xi
- Liang Zhou
Institutions
- Radboud University Nijmegen (NL)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Medizinische Hochschule Hannover (DE)
- Radboud Institute for Molecular Life Sciences (NL)
- Helmholtz Centre for Infection Research (DE)
- Centre for Individualised Infection Medicine (DE)
- Center for Experimental and Clinical Infection Research (DE)
- Artificial Intelligence in Medicine (Canada) (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1717978
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Medizinischen Hochschule Hannover