Profiling bone status indices reveals evidence of a low-turnover bone phenotype in type 2 diabetes: findings from the DiaFALL cohort
T2D was characterized by higher aBMD together with broadly suppressed BSIs, consistent with a low-turnover skeletal phenotype not captured by DXA alone. Osteocalcin og sclerostin appeared most informative. These findings support longitudinal studies to determine whether BSIs can enhance identification of skeletal fragility in T2D.
Authors
- Asger Ahlmann Bech (ORCID: https://orcid.org/0000-0002-8281-2402)
- Simon Lykkeboe
- Niels Henrik Rasmussen (ORCID: https://orcid.org/0009-0009-6324-6511)
- Aase Handberg
- Jakob Starup-Linde
- Annika Vestergaard Kvist
- Joop P. van den Bergh
- Peter Vestergaard
Institutions
- Steno Diabetes Centers (DK)
- Aalborg University Hospital (DK)
- Aarhus University Hospital (DK)
- Maastricht University (NL)
- VieCuri Medisch Centrum (NL)
- Aalborg University (DK)
Publication Details
- Journal
- Osteoporosis International
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1007/s00198-026-07850-9
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Aalborg Universitet
- Novo Nordisk
- Aalborg Universitetshospital
- Novo Nordisk Fonden