Prolonged Fever in Pediatric Dengue is Associated With Clinical Severity and Immune Dysregulation
Prolonged fever is relatively frequent in pediatric patients hospitalized with dengue and is associated with clinical severity, immune dysregulation and an increased risk of healthcare-associated secondary bacterial infections. These findings highlight the importance of close monitoring of children with prolonged fever for secondary complications and the microbiologic confirmation of suspected bacterial infections to guide timely and rational antimicrobial therapy.
Authors
- Ángela Niño (ORCID: https://orcid.org/0000-0003-2778-395X)
- Federico Perdomo-Celis (ORCID: https://orcid.org/0000-0003-0119-8306)
- Katherine Segura
- Jennifer M. Silva
- Jessica Toro
- Carlos F. Narváez (ORCID: https://orcid.org/0000-0003-0129-5210)
- Manuel A. Franco
- Luz-Stella Rodriguez
Institutions
- Pontificia Universidad Javeriana (CO)
- Hospital Universitario de Neiva (CO)
- Universidad Surcolombiana (CO)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1097/inf.0000000000005148
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00