Calcium channel blocker use is associated with longer time to first post transfusion cardiac event in lower risk MDS
• Cardiac events are frequent in lower risk (LR) MDS with iron overload (IOL) • Non-transferrin bound iron (NTBI) uptake into cardiomyocytes occurs via ZIP14 • Oxidative cellular damage takes place via reactive oxygen species formed from Fe 2+ • Cardiomyocyte ZIP14 was blocked with calcium channel blockers (CCB), blocking NTBI • We show in LR transfused MDS, CCB use associated with fewer clinical cardiac events
Authors
- Heather A. Leitch (ORCID: https://orcid.org/0000-0002-7899-2025)
- Carissa Chan (ORCID: https://orcid.org/0000-0003-3054-0879)
Institutions
- University of British Columbia (CA)
- St. Paul's Hospital (CA)
- St. Paul's Hospital (CA)
Publication Details
- Journal
- Leukemia Research
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1016/j.leukres.2026.108171
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00