Pediatric severe sepsis: epidemiology and risk factors associated with acute kidney injury
While the incidence of AKI increased from 2010 to 2019, associated mortality decreased. This likely reflects advancements in critical care that are improving survival, even as more cases are recognized. AKI, affecting 5% of PSS patients, remained a potent marker of severity, was associated with a sevenfold increased risk of mortality and driven by identifiable risk factors like specific comorbidities and infections. Enhanced early identification of at-risk children is crucial to further improve outcomes.
Authors
- H. Y. Li
- Jiannan Song (ORCID: https://orcid.org/0000-0003-1087-6658)
- Qi Zhou (ORCID: https://orcid.org/0000-0002-2699-6155)
- Ran Yu
- Jiannan Wu
- Xuegao Yu
- Hongyu Zhang
- Ying Zhang
- Zhanfei Hu
- Wanli Ma
- Hongyan Zhu
- Jian Wang
Institutions
- Sun Yat-sen University (CN)
- Chifeng University (CN)
- Chifeng Municipal Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Inner Mongolia Medical University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fped.2025.1736473
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Inner Mongolia