Age-specific vaginal microecological dysbiosis associated with HPV infection: a large-scale cross-sectional study with targeted functional sequencing validation
HPV infection selectively remodels vaginal microbiota composition and metabolic function in an age-dependent manner, with midlife women (35-44 years) representing a critical window for microbiota-based HPV prevention strategies.
Authors
- Bina Wei
- Yanfang Lu
- Hangjing Gao (ORCID: https://orcid.org/0000-0003-4549-2806)
- Fang Xie (ORCID: https://orcid.org/0000-0003-2041-2208)
- Binhua Dong (ORCID: https://orcid.org/0000-0002-5086-0696)
- Lulu Feng
- Wenjun Lin (ORCID: https://orcid.org/0000-0003-3952-3100)
- Yaojia Chen (ORCID: https://orcid.org/0000-0001-5834-0436)
- Zhihui Wu
- XiaoQi Sun
- Qing Li
- HongJing Chen
- Yue Wang
- Hao Lin
- PengMing Sun
Institutions
- Fujian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Fujian Women and Children Hospital (CN)
- Fuzhou Maternity and Child Health Care Hospital (CN)
- Children’s Hospital of Fudan University Xiamen Branch (CN)
- Xiamen Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fcimb.2025.1722367
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Fujian Provincial Health Commission