Digoxin Attenuates Ocular Hypertension and Protects Trabecular Meshwork Cells via Ferroptosis Inhibition
Our findings establish digoxin as a promising therapeutic agent that suppresses ferroptosis and reduces IOP via the SLC2A3/SCD/HBA1 pathway, providing a transformative strategy for POAG treatment.
Authors
- Xuanchu Duan
- Dan Ji (ORCID: https://orcid.org/0000-0003-2888-9342)
- Wenxiang Zhu (ORCID: https://orcid.org/0009-0007-7619-6854)
- Bo Hu (ORCID: https://orcid.org/0000-0003-1462-8854)
- Xiaoyu Zhou
- Ping Wu
- Jiahao Xu
- Zheng Li
Institutions
- Central South University (CN)
- Jinan University (CN)
- Chenzhou First People's Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Glaucoma Research Foundation (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1167/iovs.67.1.46
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00