Synergy between immune system and antibiotics drives infection control in mice
These findings provide direct experimental evidence that antibiotic efficacy requires synergy with host immunity. They highlight the therapeutic potential of augmenting innate immune activation to improve infection outcomes, particularly in immunocompromised patients.
Authors
- Athena M. Soulika (ORCID: https://orcid.org/0000-0001-6746-3876)
- Sasha H. Shafikhani (ORCID: https://orcid.org/0000-0003-1755-9997)
- Christi Thomas
- R. Rivkah Isseroff (ORCID: https://orcid.org/0000-0001-7813-0858)
- Deepa Dehari (ORCID: https://orcid.org/0000-0002-2773-0850)
- Rajalekshmy Girishkumar Padmakumari
- Foyez Mahmud
- Ruchi Roy
- Getnet Tesfaw
Institutions
- Shriners Hospitals for Children - Erie (US)
- Illinois College (US)
- University of Illinois Chicago (US)
- VA Northern California Health Care System (US)
- University of California, Davis (US)
- Thermo Fisher Scientific (Norway) (NO)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1719808
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 24.43
Funders
- National Institutes of Health
- National Institute of General Medical Sciences