Electrophysiological Evidence of Visual Dysfunction in <scp>SCA3</scp> : <scp>PERG</scp> / <scp>PVEP</scp> as Novel Biomarkers for Ataxia Severity and Cognitive Decline
We demonstrate selective retinal functional and structural impairment in SCA3, with visual electrophysiological abnormalities and SD-OCT morphological thinning significantly correlated with clinical phenotypes. Integrated with retinal functional and structural assessments, this approach provides a novel multimodal diagnostic framework and a more sensitive biomarker for SCA3 natural history studies and clinical trials. © 2026 International Parkinson and Movement Disorder Society.
Authors
- Yonghua Huang (ORCID: https://orcid.org/0000-0002-8497-4536)
- Feixue Liu (ORCID: https://orcid.org/0000-0002-8997-8165)
- Sha Li (ORCID: https://orcid.org/0000-0002-4869-3809)
- Peiling Ou
- Gang Wang
- Hao Wang
- Yanling Long
- Xi Chen
- Fanzhong Zou
- Jian Wang
- Min Wang
- Chen Liu
- Linbo He
Institutions
- Army Medical University (CN)
- Southwest Hospital (CN)
Publication Details
- Journal
- Movement Disorders
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1002/mds.70195
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Army Medical University