Dose- and Time-Dependent Halofuginone Cytotoxicity in HaCaT Keratinocytes: Implications for Cholesteatoma
HF exerts potent cytotoxic effects on keratinocytes, with efficacy increasing with exposure duration. These findings support the further study of HF as a pharmacological agent for modulating epithelial proliferation in cholesteatomas and related disorders.
Authors
- Handan Sevim (ORCID: https://orcid.org/0000-0002-8511-5258)
- Levent Sennaroğlu (ORCID: https://orcid.org/0000-0001-8429-2431)
- Burçay Tellioğlu (ORCID: https://orcid.org/0000-0003-2473-7085)
- Münir Demir Bajin
- Mehmet Ali Onur
- Esin Akbay Çetin
Institutions
- London Health Sciences Centre (CA)
- Hacettepe University (TR)
Publication Details
- Journal
- Journal of Audiology & Otology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.7874/jao.2025.00360
- Primary Topic
- Ear Surgery and Otitis Media
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hacettepe Üniversitesi