Age-period-cohort effect on motor neuron disease mortality in the United States, 2001–2020
APC analysis revealed potentially impactful age, period, and cohort effects in U.S. MND mortality between 2001 and 2020, with higher mortality among men and evidence of sex-specific cohort patterns. Cohort effects suggest potential generational differences in risk. Further investigation is needed to disentangle ascertainment effects from true etiologic influences.
Authors
- Paul Mehta (ORCID: https://orcid.org/0000-0002-0796-8861)
- Theodore Larson (ORCID: https://orcid.org/0000-0003-4719-4829)
- Jaime Raymond (ORCID: https://orcid.org/0000-0002-5594-6931)
- Theresa Nair (ORCID: https://orcid.org/0009-0000-3515-6011)
- Marc G. Weisskopf (ORCID: https://orcid.org/0000-0003-4513-9834)
- Suraya Mohidul
- John Kaufman
- D. Kevin Horton
Institutions
- Agency for Toxic Substances and Disease Registry (US)
- FIT Consulting (Italy) (IT)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fneur.2025.1751690
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centers for Disease Control and Prevention
- Agency for Toxic Substances and Disease Registry