Single-Dose Liposomal Amphotericin Plus Fluconazole and Flucytosine for Cryptococcal Meningitis at a US Public Hospital

In this pre-post study of HIV-associated CM, fewer severe adverse effects were seen in patients receiving the AMBITION protocol compared with a daily amphotericin-based regimen, with no difference in mortality or recurrence. There were also fewer patient-directed discharges, suggesting more patient-centered care. These findings support broader adoption of the AMBITION protocol in high-resource settings.