Ginsenoside Rk1 alleviates lipopolysaccharide (LPS)-induced cognitive impairment by modulating synaptic plasticity
This study provides compelling evidence that ginsenoside Rk1 effectively alleviates LPS-induced cognitive dysfunction by ameliorating neuroinflammation and significantly enhancing synaptic plasticity. The mechanistic insights suggest that these neuroprotective effects are mediated, at least in part, through the modulation of the PI3K/Akt signaling pathway.
Authors
- Funan Ning
- Li Ding (ORCID: https://orcid.org/0000-0003-0711-6906)
- Xiao Hu (ORCID: https://orcid.org/0000-0003-1128-4099)
- Zhou Lan (ORCID: https://orcid.org/0000-0002-6241-5573)
- Biqun Zhang
- Jiaqi Ji
- Ping Wang
- Xuesong Zhang
- Junzuo Zheng
- Zhiang Liu
Institutions
- Hubei University of Chinese Medicine (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fphar.2025.1747574
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hubei Province