Intensification of Treosulfan-Fludarabine Conditioning With Thiotepa Exhibited Effectiveness and Tolerability in Older or Comorbid Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant With Active Myeloid Neoplasm: A Real-world Study

Our results confirmed the efficacy and tolerability of the TF regimen in older or comorbid AML and MDS patients in the real-world setting and suggest that double alkylation might counterbalance the adverse outcome risk posed by active disease at alloSCT. Furthermore, larger, prospective studies are needed to better elucidate the patients for whom the addition of thiotepa might be most beneficial.