Training and validation of a nomogram for predicting synchronous distant organ metastasis in patients with very-early-onset colorectal cancer

The predictive nomogram, derived from demographic, clinical, and pathological data from the SEER database, provides an estimation of the DOM risk in VEO-CRC patients. This is a promising tool to improve outcomes for young patients by assisting physicians in early risk stratification and bespoke treatment planning. At prespecified risk thresholds, the predicted probabilities may assist early risk stratification and inform imaging and follow-up decisions, though their clinical application will require confirmation through rigorous external validation.