<i>Streptococcus lutetiensis</i> septicemia in a 3-month-old reticulated giraffe calf

<i>Streptococcus lutetiensis</i> is a gram-positive organism in the non-enterococcal Lancefield group D <i>Streptococcus bovis/S. equinus</i> complex. <i>S. lutetiensis</i> has been reported as a cause of septicemia, endocarditis, and meningitis in humans, mastitis in dairy cows, and systemic streptococcosis in sea otters. A 3-mo-old reticulated giraffe (<i>Giraffa reticulata</i>) with a history of suspected failure of passive transfer (FPT) was submitted for postmortem examination, revealing bacterial septicemia, fibrinosuppurative polyarthritis, and embolic glomerulonephritis, with intravascular gram-positive cocci and microthrombosis in multiple organs. Bacterial culture and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry detected <i>S. lutetiensis</i>. <i>S. lutetiensis</i> septicemia was likely the result of FPT in this giraffe calf.