Alzheimer Disease–Relevant Biomarker Elevations in Psychosis and Broad Neuropsychiatric Impairment

This cohort study examines the association of serum hyperphosphorylated tau and neurofilament light chain concentrations with psychosis in Alzheimer disease.

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Journal
JAMA Psychiatry
Published
2026-01-21
DOI
https://doi.org/10.1001/jamapsychiatry.2025.4347
Primary Topic
Alzheimer's disease research and treatments
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article
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article

Alzheimer Disease–Relevant Biomarker Elevations in Psychosis and Broad Neuropsychiatric Impairment

Arjun V. Masurkar, Robin Bean, Debra Ordor, Kathyrn Turner et al.
JAMA Psychiatry
Alzheimer's disease research and treatments
article

Alzheimer Disease–Relevant Biomarker Elevations in Psychosis and Broad Neuropsychiatric Impairment

Arjun V. Masurkar, Robin Bean, Debra Ordor, Kathyrn Turner, Amanda Smith, Eboni N. Walker, Choe Ma, Justin M. Long, Beverly Meacham, David J. Mossa, Jim J. Pekar, Michael Asbach, Abigail O’Connell, T. F. R. Hamm, K J Ayers, Ruchi Aggarwal, Amanda C. Glueck, Ilya M. Nasrallah, Karen L. Blank, Serena Lowery, Courtney Dawson, Sheryl Lynch, Andrea Kippels, Laili Soleimani, Cesar Chirinos, Javed Khan, Corey Demsky, Christopher B. Morrow, Béla M. Ajtai, Trung Dung Nguyen, Emmeline Lin, Maria Scanlan, Marilyn Albert, Miriam T. Ashford, Chadwick M. Hales, Jaimie Ziolkowski, Marissa Natelson-Love, Mingkai Chen, Daniel W. Bandy, Michael S. Rafii, Rachael Penn, Marie Bernard, Bryan L. Smelser, F. E. Jones, N B Mathis, Payam H. Mahboubi, Adaora Ngozi Nwosu, Cecily Jenkins, Michael Donohue, MaryAnn Oakley, Lesley K. Rao, Ronald Killiany, Laura Goins, Eric Steinberg, Bradley Wallace, Kwangslk Nho, Jacob S. Shaw, Lorena Monserratt, Heather Polson, Sunnie Kenowsky, Kayla Nichols, Soumya Bouchachi, Sandra E. Black, Caila Ryan, Charles Bernick, Diana Truran Sacrey, Ara Ko, Romina A. Romero, Gary R. Cornell, Marjan Farshadi, Traci Aladeen, Matthew L. Senjem, Haley Bernhardt, Carolyn English, Emily D. Clark, Jessica M. Mallory, PAUL A. NEWHOUSE, Abey Thomas, J Harp, K Lacy, Susan P. Good, Shaundra Hall, Rawan Tarawneh, Frances E. Jensen, Alexandra Groome, Cyrus A. Raji, Martha R. Forloines, Michael L. Alosco, Kelly McCann, L T Quinlan, Grace Nelson, Rachel L. Henson, M Masellis, David Thomas Jones, John C. Morris, Cynthia Stover, L Barlow, Bonomi Robin, Abhay Moghekar, Denise Alexandra Chavez Reyes, Emily Little, Kelly M. Durbin, Molchan Se, Connie Mayo, Veronika Solomon, Paula Ogrocki, Michelle G. Villar, Felmlee JP, Yang Wan, Ian B. Malone, M Nguyen Thao, Thomas C. Hawk, Meghan C. Riddle, Regan Buckler, Leila Parand, Evan T. Schulze, James M. Brewer, Terence Z. Wong, Vanessa Guzmán, Melanie J. Miller, S MCKINZIE, Tia C. Hall, Tahlee Marian, Richard H. Le, Roderick McColl, Joseph Boonsiri, Alexandra Dahlgren, Samantha Fikru, Mike Nguyen, Maryam Beigi, Hamid Reza Okhravi, Anish Kapadia, Adam J. Fleisher, J. A. Mahaffey, Casie K Lyons, Kandise Chrestensen, Mariana Palou, Jane Mwicigi, Michelle L. Hernandez, Hitesh Patel, Robert Bryant, Iris Marion Young, Brendan Lynch, Lisa Laverne Barnes, Kelsey King, Connie Kreuger, Zach Bonacorsi, Xiomara Mendoza Apuango, Sheryl Detling, Barbara Rodzon, Emilie Geesey, Emily Petrocca, Ann Arlene Malia, Patricia Wiesenauer, Kimberly Nelsen, Skieff Acothley, Haley Hendrix, Bethanie Gamble, Morgan Yazell, Xanthia Saganis, Aaliyah Korkoyah, Emily Roglaski, John Moore-Weiss, Leonard Matoush, Dariya Malyarenko, Renee LaBarge, Victoria Rufo, Veronica Briglall, Ivan Mares, Jahmila Al-Amin, Sarah Basadre, Heather Dooly, Katelynn Kreszyn, Aferdita Haviari, Nicole DaSilva, Shaniya Parkins, Kejal Kantarci, K C Evans, Brandi Barger, REMA RAMAN, Maushami Gurung, Lisa Thomas, VJ Lowe, Carole Ho, Jacob Faircloth, Nathiel Pacini, Cammie Hellegers, Ezequiel Zamora, Charles J. Duffy, Edward B. Lee, Robert Hernandez, E. Schwartz, Akiva Mintz, Nicole Barcelos, Kelly Larkin, J. Plenge, Tiffani Fox, Tracey Moore, Jennifer Salazar, Jasmine Stewart, Oshoze Kadiri, Jessica Magnuson, Maria Chaudhary, Abbey Arnold, Nicole Gagliano, Tatianne Martinez, Patricia Place, Matalin Miller, Haley Tong, Kedir Adem Hussen, Stephanie O'Malley, Amy Browning, Lorena Macias, Gregory S Day, Ina Hoti, Ombolanle Ayo, Michael Asbach, Seth Gale, Zoe Lin, James J. Lah, Catherine E Munro, Hannatu Amaza, Allison L Perrin, Taeho Jo, Kelley M. Faber, Charna Bates, Agathe Vrillon, Alex Groves, Chengshi Jin, Ryan S O'Dell, Juris Janavs, Aimee Pierce, Yanan Shang, Warren W Barker, Amy Perkins, Robin Hsiung, Andrew Ellison, Wendy Baker, Maribel Nunez, Alka Khera, Paul Malloy, Cindy Parry, Thao Rodriguez, Martin Ayres, Chelsea Reichert, Ricardo Salazar, Guy Harris, Jason Weller, Christina Rosario, Amanda Jimenez, Jan Clark, Laura Donnelly, Nadeen Elayan, Chuang-Kuo Wu, Hongzheng Zhang, Allison Lapins, Jennifer Bray, Sanjay Asthana, Lisa C Silbert, Adeyinka Ajayi, Nichol Ferng, Sarah Munie, Tera Clay, Andrea Fidell, Diana Ferman, Scott Neu, Madiha Fairooz, Loren Brown Ashley, Adrienne Kormos, Taylor Clanton, Kristin Oleary, Cat Conti, Tanya Harte, Gina Garcia-Camilo, John K Hsiao, Emily Largent, Blake Vogler, Kara Wever, Maria Kataki, Sheila Ogwang, Gregory Ikner, Regan Brooks, Jeff Gunter, Joshua D. Grill, Crystal Duncan, Clifford R. Jack, Brendan Kelley (031), Maria Carrillo, Andrew J. Saykin, Bridget Holvey, Joanne Lim, Traci Day, Delaney Fragale, Brandon Anderson, Vijay Ramanan, Martha Combs, Carolyn Ward, Alison Pietras, Cierra McCurry, Vanessa Clayton, Hugo Botha, John Rogers, Lora Gallagher, Meagan Yong, Scott Herring, Howard Chertkow, Morris Wishnia, Rebecca Long, Patricia O'Donnell, Kevin Hopkins, Richard Zawislak, Candy Monarrez, Nicole Johnson, Tara Villinger, Stephen Correia, Morgan Blackburn, Jenny Echevierra, Carol Cline, Hadley Hustead, Sara Manning, Jennifer Frascino, Katie Vo, William Jagust, Jonathan Jackson, V. Sotelo, Pierre Tariot, Paul Thompson, Anton Porsteinsson, Kathleen Johnson, Anne Arthur, Leon Thal, Susan DeStefano, Mary Sano, Aaron Jacobosn, Brigit Lieb, Hillel Grossman, Neda Jahanshad, Princess Carter, Zoë Potter, Inara Jooma, Jason Karlawish, Kathy King, Michele Gutierrez, Crystal Flynn Longmire, Caroline Smith, Elaheh Salardini, Jessica Harkins, Sarah Ash, Rebecca Devine, Alexis DeMarco, T-Y Lee, Andrew Kertesz, Russell Kurvach, Barbara Hackenmiller, Victor Villemagne, William Harrison, Thomas Obisesan, Emma Cooper, Alicia Jessup, Kerstin Doyon, Laszlo Mechtler, Jelena Pejic, Scott McGinnis (094), Jonathan Cordona, Parichita Choudhury, Hannah Craft, Amber Khan, Diego Mejia, William Potter, Jeffrey Burns, Erin Murphy, Olga Brawman-Mintzer, Talia M. Nir, Luter Liu, Bennett Myers, Pamela Friedman, Erin Yurko, Steven Presto, Gaby Thai, Jessica Morales, Ella Wright, Elaine Most, Lisa Schoolcraft, Aparna Bhan, Anthony Daley, Rebecca Hunt, Lisa Rankin, Nunzio Pomara, Katie Seidenberg, Michael Glass, Christopher van Dyck, Neetha Basheer, Gil Rabinovici, Jennifer Johns, Magdalena Korecka, Glen Nyborg, Kylee York, Yair Avila, Kristin Harkins, Evan Fletcher, Francisco Rivera, Jeffrey Maneval, Adam Mecca, Natalie Martinez, Kaori Kubo Germano, Sarah Berman, Pallavi Sachdev, Arthur Williams, Socorro Trujillo, Faye Sheppard, Yanis Cavrel, Regina M. Silver, Paige C Tracey, Karen Nolan, Mikhell White, Vita Pomara, Jeffrey Bishop, Arthur W. Toga, Sarah Jefferson, Horacio Capote, Jeffrey Petrella, Samantha Rogers, Richard J. Perrin, Elisa Hidalgo, Costin Tanase, Elizabeth Cheatham, Joanna Gonzalez, Alexa Puleio, Monica Rivera-Mindt, Sarah Walter, Joe Strong, Katherine Stapleton, Madison DeCapo, Gillian Devereux, Tatiana M. Foroud, Stephen D'Ambrosio, Mary Imhansiemhonehi, Claire Erickson, Raj Shah, Melissa Hamski, Ajay Sood, Kirsten Glennon, Bevan Hoover, Ellen Hartman, Cynthia Munoz, Laura Ashe, Steven Lenio, Carolyn Liebsack, Stacy Pot, Jeffrey Kaye, Triana Rudd, Sochenda Stephens, Ruby Endre, Melanie Tallakson, Kerry Crawley, Ijeoma Mba, Doris Chen, Michael Callan, Josalen Gondrez, Tuba Ahmed, Paul Eigenberger, Amber Watkins, Emma Brennan, Fatima S. Amtashar, Konstantinos Chiotis, Paula Nunes, Teresa Kalowsky, Chris Figueroa, Steven Tam, Michelle McDonnell, Anna Mattle, Stephanie Reeder, Immaculata Okonkwo, Christopher Schwarz, Ariana Moss, Martin Farlow, Kimberly Martin, Maria Acevedo, James O'Connor, Abigail Mathewson, Nigel J. Cairns, Dick Trost, Kathryn Moorlach, Allan Levey, Pauline Wu, Anh Tran, Jessica Swiniarski, Benjamin Lam, Chi Kim, Isabell Mwaura, Alayne Nieto, Julia Waszak, Nicole Robert, Shannon L. Risacher, Violet Wenner, Maria Gallegos, Zaven Kachaturian, Scott Warren, Terry Camarro, Sophia I. Thomopoulos, Donna Munic, Amy Boegel, Adam Diaz, Margaret Bassett, Minal Vasanawala, Leena Lukose, Sarah Binder, Raymond Scott Turner, Susan Landau, Robert Swarm, Gilberto Perez, Yaakov Stern, Charles DeCarli, Alyssa Ton, Brittany Marti, Sari Pham, Joseph Masdeu, Chad Ward, Tolulope Alo, Richard Frank, Jennifer Rowell, Jillian Turner, Rachel Nosheny, Ala Abusalim, Amelia Troutman, Kimberly Jackson, Gregory Pontone, Chris Hosein, Anton Thomas, Steven MacDonald, Cyndy Toso, Alzheimer’s Disease Neuroimaging Initiative, Mauro Veras Acosta, Maria Corona, Emily McKinley, P. Murali Doraiswamy, Dr Rob Bartha, J.Q. Trojanowki, Ali Raja, Rebecca Taylor, Paul A. Yushkevich, Eliezer Masliah, Jonathan Graff-Radford, Abby Brown, Helena Colvee, Ronald Bailey, Ashton Ellison, Danielle Goldfarb, Allison Emborsky, Virginia Boatwright, Arvin Forghanian-Arani, Donna Veronelli, Maria Greig-Custo, Megan King, Brett Borowski, Alexandria Montero, Prabin Mandall, Ridiane Denis, Kailey Basham, Ryan Townley, Lauren Garcia, Hector M. González, Phillip "Hunter" Ledford, Juliet Fockler, Samira Yeboah, Neill Graff-Radford, Sarah Bohlman, Lawrence Honig, Mercedes Madison, Joshua Knaack, Judith Heidebrink, Lindsey Hergesheimer, Lon Schneider, Katlynn Patterson, Serena Cepeda, Heather Klemp, Linda Watts, Tatiana Jimenez-Knight, Erin Westerhold, Sandra Talavera, Heather Nicole Elmore, Alisa Adhikari, Richard King, Duygu Tosun, Carl Sadowsky, Paul Aisen, Audrey Ruan, Amy Saklad, Caileigh Zimmerman, Dylan Wint, Joseph Bottoms, Alyssa Miller, Amanda Brennan, Caitlin Webb, Renaud La Joie, Esmeralda Morales, James Ruszkiewicz, Katherine Britt, Ranjan Duara, Steven Smith, Campbell Long, Jared Brosch, Isabella Ramirez, Marwan Sabbagh, Kenneth Spicer, Arun Ramamurthy, Stefka Lyron, Michelle Assaly, Stephanie de Santiago, Ifreke Udodong, Jennifer Horenkamp, Victoria Sanborn, Jade Uffelman, Wendy Stewart, Stephanie Smith, Sarah Malakauskas, Ycar Devis, Heather Rose, Walter Martinez, Kevin Epperson, Terra Burney, Sandra Calderon, Wendy Qiu, Robert B. Santulli, Elizabeth Trejo, Todd Peehler, Dana Mathews, Jennifer Ramirez, Kyliah Hughes, Maison Abu Raya, Michael Holt, Cynthia M. Carlsson, Beatriz Vides, William Hu, Kirsten Hendrickson, Zhala Taghi-Zada, Latasha Chapman, Marianne Sanders, Hannah McCoubrey, Douglas W. Scharre, Elizeva (Ellie) Phillips, Kimberly Blanchard, Sylvia Vincent, Olga James, Laurie Ryan, Sonia Olgin, Fabiola Magana, Molly Goddard, Elizabeth Robinson, Sanjeev Vaishnavi, Nadira Trncic, Freda Crawford, Ava Stipanovich, Sterling Johnson, Karen Dagerman, Debra Silberberg Kovac, Richard Isip, Zaven Khachaturian, Nathaniel Houghtaling, Giuseppe Esposito, Michael J. C. Bray, Brian LoPresti, Susan Henkle, Stephanie Rossi Chen, Michael W. Weiner, Genesis Burgos-Rivera, Roberta Calzavara, Oscar Lopez, Bradley Boeve, Aidyn Rose Hills, Cary Zik, Arlene Richards, Mary Nguyen, Catie Hedberg, Li Shen, Howard J. Rosen, Michaela Johnson, Olivia Schultz, Sydni Jenee Hill, James Bateman, Matt Glittenberg, Jennifer Davis, Peter J. Snyder, Mary Locke, Rebecca Logan, Trinity Weisensel, Joseph Di Benedetto, Stacey Winterton, Martin Pomper, Valory Pavlik, Lena Moretz, Gillian Gabriel, Raymundo Hernando, Roxanne Polleys, Mayer Joshua Hasbani, Edgardo Rivera, Asa Widman, Michael Shannon, Anjana Mandal, Christopher Scott, Jeff Williamson, Alexander (Alex) Frolov, Danielle Harvey, Skylar Wilson, Nina Silverberg, Godfrey D. Pearlson, Virginia Rogers, Lauren Jennings, Nick C. Fox, Kelly Nudelman, James Webster, Benjamin Wagner, Matthew R. Jones, Jennifer Wong, Angelica Garcia, Elizabeth Shaffer, Siddharth Khasnavis, Maya Farchi, Jesse Mez, Christine Dittrich, Donna Masterman, Allison Ardolino, Tuan Luu, Jessica Lam, Jeanine May, Maria Toth (fmr Gross), Marie Amoyaw, Sarab Singh, Derek Flenniken, Maria Samira Gutierrez, Linda Fenice, Kathleen Savage, Olusegun Adegoke, Meghan Mitchell, Nasrin Ghesani, Samantha Sullivan, Andrea Williams, Jaila Coleman, Phyllis Vaughn, Sonia Pawluczyk, Robert Reid, Lauren Mariotti, Sonia Garrison, A'llana Marolt, Ljubica Zotovic, Deb Thompson, Melissa Yu, Lisa Taylor-Reinwald, Robert A. Koeppe, Randall Barker, Allison Acree, Eugene Yau, Erin Drake, Yaneicy Gonazalez Rojas, Elizabeth McCorkle, Mona Lauture, Harold Matthew Cooper, Rachel Rovere, Gladiliz Rivera-Delpin, Sandhitsu Das, Meghan Sinn, Jesse Stanhope, Karen Anderson, Madeline Paczynski, Bruce L. Miller, Kayley Lawrence, Brittney Luong, Mauricio Becerra, Jennifer Ryan, Daniel Schwartz, Naomi Saito, Alireza Atri, Sylvia Grant, Erawadi Singh, Dorothy Ross, Saurabh Sharma, Liana G. Apostolova, Sarah Bowser, Della Carter, Daryn Slazyk, Audrie Swain, Sallie Carpentier, David Bissig, Queennie Majorie S Kahulugan, Maurylette Gui, Kelly Wallace, Andrew Stone, Lindsey Booth Robbins, Lynn Nguyen, Heather Russell (116), Meghan Donahue, Carlota Conant, Ellen Kim, Prashanthi Vemuri, David Geldmacher, Chiadi U. Onyike, Amy Rangel, Courtney Williams, Amy Thomas, Julien Lagarde, Erin Fransen, Sylvia White (Salazar), Ian Grant, Laurel Beckett, Rima Kaddurah-Daouk, Justin Robison, Katherin Martin, Loreece Haddad, Steven Chao, Edward B. Lee, Karen Gagnon
article en

Abstract

This cohort study examines the association of serum hyperphosphorylated tau and neurofilament light chain concentrations with psychosis in Alzheimer disease.

JAMA PsychiatryVol. 83(3)
Johns Hopkins University (US), Johns Hopkins Medicine (US), Alzheimer’s Disease Neuroimaging Initiative (US)
Openalex Percentile: Top 83%
Alzheimer's disease research and treatments
DOIOpen Access PDFOpenAlex
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