Investigating Biomarkers for Inborn Errors of Immunity in a Prospective Study of Patients With Autoimmune Cytopenia
Quantitative immunoglobulin levels and naïve T cells remain valuable indicators of IEI in AIC. Our findings highlight the diagnostic value of emerging cellular and serum biomarkers in identifying IEI, including dysregulation of early B-cell subsets (transitional B cells and CD19<sup>hi</sup>CD21<sup>lo</sup> B cells), expansion of T<sub>FH</sub> cells, and elevated levels of BAFF and sIL2R.
Authors
- Don Eslin (ORCID: https://orcid.org/0000-0003-3812-3498)
- Anna L. Meyer (ORCID: https://orcid.org/0000-0002-4833-8014)
- Jonathan Metts (ORCID: https://orcid.org/0000-0003-1068-7857)
- Elvin M. Mendez (ORCID: https://orcid.org/0000-0001-9700-4304)
- Panida Sriaroon (ORCID: https://orcid.org/0000-0002-6937-7303)
- Amanda R. Schlefman
- Mark C. Glaum
- Boglárka Ujházi
- Joseph Dasso (ORCID: https://orcid.org/0000-0001-8917-8603)
- Melis Yilmaz (ORCID: https://orcid.org/0000-0002-8506-7372)
- Andrew Galligan (ORCID: https://orcid.org/0000-0002-6829-5074)
- Erin Cockrell (ORCID: https://orcid.org/0000-0003-3016-4471)
- Dana Obzut
- Benjamin Oshrine (ORCID: https://orcid.org/0000-0002-2836-2244)
- Jane Purser
- Akaluck Thatayatikom (ORCID: https://orcid.org/0000-0001-7977-9237)
- Bodo Grimbacher (ORCID: https://orcid.org/0000-0002-6897-6806)
- Maryssa Ellison
- Emily Weis
- Cristina Meehan (ORCID: https://orcid.org/0000-0002-5165-9521)
- Frank Ayestaran Cassani
- Marisol Betensky (ORCID: https://orcid.org/0000-0001-6725-3035)
- Irmel Ayala
- Kranthi Nomula
- Daime Nieves
- Merve Nida Gokbak (ORCID: https://orcid.org/0000-0002-9220-9455)
- Brady Franson
- Diana S. Milojevic
- Jennifer Mayer (ORCID: https://orcid.org/0000-0003-0576-2058)
- Alina Ramirez
- Rahim Miller
- Shalin Shah
- Ahmad Shaker
- L E Santiago
- Manish J. Butte
- Zsuzsanna Gaal
- Evan Potts
- Paola Suhet
- Bijal D. Shah
- David Rosenberg
- Alfred Asante‐Korang
- Priya Patel
- Meagan Anne Cooper
- John Prpich
- Mark Minor
- Marta Toth
- Jocelyn R. Farmer
- Rachel Cruz
- Emma Westermann‐Clark
- Sumai Gordon
- Jolan E. Walter
- Mei‐Sing Ong
- Krisztian Csomos
Institutions
- University of Debrecen (HU)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- Washington University in St. Louis (US)
- University of South Florida (US)
- Holmes Regional Medical Center (US)
- University Medical Center Freiburg (DE)
- University of Rochester Medical Center (US)
- Moffitt Cancer Center (US)
- University of Alabama at Birmingham (US)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
- Allergy Clinic of Tulsa (US)
- James A. Haley Veterans' Hospital (US)
- Los Angeles Medical Center (US)
- Johns Hopkins All Children's Hospital (US)
- ENT and Allergy (US)
- BayCare Health System (US)
- Lahey Medical Center (US)
- AdventHealth for Children (US)
- Harvard Pilgrim Health Care (US)
- Lee Memorial Health System (US)
- Florida Cancer Specialists & Research Institute (US)
- St. Joseph's Children's Hospital (US)
- Stanford Medicine (US)
- Asthma Association (BG)
- Dermatology Specialists (US)
- UMass Memorial Medical Center (US)
- Tampa Bay Research Institute (US)
- Stanford University (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1002/1545-5017.70074
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00