Study on Correlation of Umbilical Cord Arterial Blood pH with Perinatal Asphyxia and Early Neonatal Outcome

Background: Perinatal asphyxia is a leading cause of neonatal morbidity and mortality. Umbilical cord arterialblood pH is a key marker for assessing asphyxia severity and its impact on neonatal outcomes, particularlyhypoxic ischemic encephalopathy (HIE).Objectives: To investigate the correlation between umbilical cord arterial blood pH and perinatal asphyxia,focusing on its relationship with early neonatal outcomes, including HIE and the need for resuscitation.Methods: This cross-sectional study at GMC Kota included 131 neonates with suspected perinatal asphyxia.Umbilical cord pH and neonatal outcomes, including HIE, were analyzed. Statistical analysis was performedusing SPSS 24.0, with p<0.05 considered significant.Results: Among 131 neonates, 67.2% were born at 37-39 weeks. Pregnancy-induced hypertension was the mostcommon risk factor. APGAR scores improved significantly over time. The mean umbilical cord pH was 6.9,indicating acidosis, and 39.7% of neonates had grade 3 HIE. No significant correlation was found betweenmeconium-stained liquor and perinatal asphyxia (p=0.745).Conclusion: Umbilical cord pH is a critical marker for perinatal asphyxia and its associated outcomes,including severe HIE. The lack of correlation between meconium-stained liquor and asphyxia warrants furtherinvestigation

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Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-11-21
DOI
https://doi.org/10.5281/zenodo.18322557
Primary Topic
Neonatal and fetal brain pathology
Type
article
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article

Study on Correlation of Umbilical Cord Arterial Blood pH with Perinatal Asphyxia and Early Neonatal Outcome

Monika Dhakad, Pankaj Kumar Singhal, Sakshi Shringi
Zenodo (CERN European Organization for Nuclear Research)
Neonatal and fetal brain pathology
article

Study on Correlation of Umbilical Cord Arterial Blood pH with Perinatal Asphyxia and Early Neonatal Outcome

Monika Dhakad, Pankaj Kumar Singhal, Sakshi Shringi
article en

Abstract

Background: Perinatal asphyxia is a leading cause of neonatal morbidity and mortality. Umbilical cord arterialblood pH is a key marker for assessing asphyxia severity and its impact on neonatal outcomes, particularlyhypoxic ischemic encephalopathy (HIE).Objectives: To investigate the correlation between umbilical cord arterial blood pH and perinatal asphyxia,focusing on its relationship with early neonatal outcomes, including HIE and the need for resuscitation.Methods: This cross-sectional study at GMC Kota included 131 neonates with suspected perinatal asphyxia.Umbilical cord pH and neonatal outcomes, including HIE, were analyzed. Statistical analysis was performedusing SPSS 24.0, with p<0.05 considered significant.Results: Among 131 neonates, 67.2% were born at 37-39 weeks. Pregnancy-induced hypertension was the mostcommon risk factor. APGAR scores improved significantly over time. The mean umbilical cord pH was 6.9,indicating acidosis, and 39.7% of neonates had grade 3 HIE. No significant correlation was found betweenmeconium-stained liquor and perinatal asphyxia (p=0.745).Conclusion: Umbilical cord pH is a critical marker for perinatal asphyxia and its associated outcomes,including severe HIE. The lack of correlation between meconium-stained liquor and asphyxia warrants furtherinvestigation

Zenodo (CERN European Organization for Nuclear Research)
Mother Hospital (IN)
Good health and well-being
Openalex Percentile: Top 15%
Neonatal and fetal brain pathology
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