Glutamate load fosters spreading depolarization under osmotic stress in brain slices
These findings demonstrate that astrocyte volume regulation and neuronal ionotropic glutamate receptors jointly shape SD characteristics under osmotic stress, identifying astrocytic water/ion homeostasis and glutamatergic signaling as potential therapeutic targets to limit excitotoxic injury in acute cerebrovascular disease.
Authors
- Eszter Farkas (ORCID: https://orcid.org/0000-0002-8478-9664)
- Rita Frank (ORCID: https://orcid.org/0000-0003-2342-9937)
- Ákos Menyhárt (ORCID: https://orcid.org/0000-0002-1355-3208)
- Stéphane Marinesco (ORCID: https://orcid.org/0000-0003-2712-6263)
- Ferenc Bari
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- United Cerebral Palsy (US)
- Inserm (FR)
- University of Szeged (HU)
- Centre de Recherche en Neurosciences de Lyon (FR)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fncel.2025.1722194
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Magyar Tudományos Akadémia
- Centre National de la Recherche Scientifique
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- Szegedi Tudományegyetem
- Nemzeti Kutatási, Fejlesztési és Innovaciós Alap
- National Research, Development and Innovation Office