Lifelong trajectories of modifiable vascular risk factors and relation to cerebral small vessel disease in the Framingham Heart Study
Individuals following high risk lifetime patterns of vascular risk factors have higher CSVD burden later in life. These results highlight the importance of primordial and primary prevention with sustained risk factor management across the lifespan to mitigate CSVD burden, a strong determinant of stroke and dementia risk.
Authors
- Andreas Charidimou (ORCID: https://orcid.org/0000-0001-5891-337X)
- Jose Rafael Romero (ORCID: https://orcid.org/0000-0002-1101-2950)
- Adlin Pinheiro (ORCID: https://orcid.org/0000-0002-4241-9198)
- Hugo J. Aparicio (ORCID: https://orcid.org/0000-0001-8584-1455)
- Oluchi Ekenze (ORCID: https://orcid.org/0000-0002-2510-8427)
- Jayandra J. Himali
- Serkalem Demissie
- Shariq Mohammed
- Alexa S Beiser
- Charles DeCarli
- Sudha Seshadri
- Vasileios-Arsenios Lioutas
Institutions
- Boston University (US)
- Beth Israel Deaconess Medical Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- Institute for Neurodegenerative Disorders (US)
- University of California, Davis (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-19
- DOI
- https://doi.org/10.64898/2026.01.16.26344309
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00