Silver Ion Assisted Paper Spray Ionization Mass Spectrometry for Bisphenols and Derivatives Analysis

Silver ion was applied in paper spray ionization mass spectrometry (PSI MS) to assist the ionization of bisphenols and derivatives including bisphenol A (BPA), bisphenol B (BPB), and bisphenol A bis (allylether) (BPA-BAE). By using the silver ion assisted paper spray ionization (SIA PSI), the intensities of BPA, BPB, and BPA-BAE were improved approximately 62, 90, and 58 times under positive mode and 1900, 1980, and 23 250 times under negative mode. Linear relationships for BPA were established within the concentration range of 0.002-1 mM, exhibiting strong correlation coefficients. The limit of detection for BPA can achieve 7.4 × 10^-5 mM. BPA in plastic sample and complex biological samples were also successfully detected by SIA PSI.