The association of clozapine treatment periods with incidence of exposure to assault and head injuries - a cohort study of electronic health records
People with schizophrenia experience violent victimization, and interventions to reduce this risk are needed. We tested the association of clozapine treatment with risk of exposure to assault and head injuries using electronic health records linked to a national clozapine treatment register and to national hospitalization data. The unadjusted incidence rate ratio (IRR) for clozapine treatment on exposure to assault and head injuries was 0.44 (95% confidence interval [CI]: 0.28-0.69). This effect remained statistically significant after covariate adjustment (0.46 (0.29-0.74); 0.40 (0.22-0.71) in men; 0.64 (0.29-1.43) in women. Clozapine treatment was thus associated with a substantially reduced risk of exposure to assault and head injuries.
Authors
- Amelia Jewell (ORCID: https://orcid.org/0000-0002-0887-2159)
- Risha Govind (ORCID: https://orcid.org/0000-0001-9925-7866)
- Vishal Bhavsar (ORCID: https://orcid.org/0000-0001-7519-0599)
- James Hunter MacCabe (ORCID: https://orcid.org/0000-0002-6754-1018)
- Francesca Kingston
- Robert Stewart
Institutions
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fpsyt.2025.1704073
- Primary Topic
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- South London and Maudsley NHS Foundation Trust
- King's College Hospital NHS Foundation Trust
- UK Research and Innovation
- National Institute for Health and Care Research
- Department of Health and Social Care
- King's College London
- NIHR Maudsley Biomedical Research Centre
- Medical Research Council
- National Institute for Health Research Applied Research Collaboration South London