MRGPRX2-expressing mast cells are increased in the GI tract of individuals with active inflammatory bowel disease and hereditary α-tryptasemia

These findings suggest that enhanced MRGPRX2 expression and mast cell activation may contribute to gastrointestinal symptoms in individuals with HαT, particularly in the setting of IBD. As interest in precision immunogenetics grows, defining mast cell phenotypes linked to α-tryptase copy number may help refine diagnostic evaluation and identify patients who could benefit from emerging mast cell-targeted therapeutic strategies in the context of IBD.

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Publication Details

Journal
Frontiers in Allergy
Published
2026-01-21
DOI
https://doi.org/10.3389/falgy.2025.1726096
Primary Topic
Mast cells and histamine
Type
article
Field-Weighted Citation Impact
0.00

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article

MRGPRX2-expressing mast cells are increased in the GI tract of individuals with active inflammatory bowel disease and hereditary α-tryptasemia

Dhana Llivichuzhca-Loja, Sangita Sutradhar, Anna H. Owings, Tanya Robinson et al.
Frontiers in Allergy
Mast cells and histamine
article

MRGPRX2-expressing mast cells are increased in the GI tract of individuals with active inflammatory bowel disease and hereditary α-tryptasemia

Dhana Llivichuzhca-Loja, Sangita Sutradhar, Anna H. Owings, Tanya Robinson, Sarah Camille Glover, Neha S. Dhaliwal, Konnikova Liza, Jonathan J Lyons, Steve Everman, Hydar Ali, Michelle Galeas-Pena, Katelyn White, Alexander Carlye, Ghina Yaghi
article en

Abstract

These findings suggest that enhanced MRGPRX2 expression and mast cell activation may contribute to gastrointestinal symptoms in individuals with HαT, particularly in the setting of IBD. As interest in precision immunogenetics grows, defining mast cell phenotypes linked to α-tryptase copy number may help refine diagnostic evaluation and identify patients who could benefit from emerging mast cell-targeted therapeutic strategies in the context of IBD.

Frontiers in AllergyVol. 6
Tulane University (US), University of Mississippi Medical Center (US), Yale University (US), University of California San Diego (US), VA San Diego Healthcare System (US), University of Pennsylvania (US)
Crohn's and Colitis Foundation of America, University of Pennsylvania, National Institute of Allergy and Infectious Diseases
Good health and well-being
Openalex Percentile: Top 82%
Mast cells and histamine
DOIOpen Access PDFOpenAlex
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MRGPRX2-expressing mast cells are increased in the GI tract of individuals with active inflammatory bowel disease and hereditary α-tryptasemia — Dhana Llivichuzhca-Loja, Sangita Sutradhar, et al. · Frontiers in Allergy (2026) | TGRS Research Map | TGRS