Fibroblast-targeted MLN4924 suppresses autoimmune myocarditis by dually modulating IL-17A and TGF-β pathways
MLN4924 exerts dual anti-inflammatory and anti-fibrotic effects in autoimmune myocarditis by regulating IL-17A and TGF-β pathways in CFs. Fibroblast-membrane camouflaging enhances MLN4924 delivery and performance, presenting a promising precision medicine strategy for immune-mediated cardiac injury with clear translational potential.
Authors
- Wenwen Chen
- Fei Guo (ORCID: https://orcid.org/0000-0003-3981-272X)
- Jiapeng Gao
- Lieying Fan
- Ming Zong
- Mengyu Huang
- Min Li
- Hao Jiang
- Jiayi Yuan
- Zhaoda Yu
- Wenwen Shen
Institutions
- Tongji University (CN)
- Second Military Medical University (CN)
- Soochow University (CN)
- Changhai Hospital (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1016/j.intimp.2026.116206
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00