Trends in the Management of Bladder Cancer with Emphasis on Frailty: A Nationwide Analysis of More Than 49,000 Patients from a German Hospital Network
This study shows frailty-specific changes in hospitalisation patterns and inpatient management of BC in Germany, underscoring the value of frailty assessment in population-based research. The proportion of patients classified as having low frailty increased over time. Significant changes in the use of intravesical chemotherapy and systemic therapy were associated with frailty. The decline in early intravesical chemotherapy may have implications for recurrence risk and downstream healthcare utilisation.
Authors
- Michela de Martino (ORCID: https://orcid.org/0000-0002-6569-300X)
- Sven Hohenstein (ORCID: https://orcid.org/0000-0002-9708-1593)
- Ralf Kuhlen (ORCID: https://orcid.org/0000-0002-4670-6127)
- Nora F. Dengler (ORCID: https://orcid.org/0000-0001-7783-8053)
- Frederic Bold
- Tobias Klatte
- Julius Dengler
- Thomas Steiner
- Andreas Bollmann
Institutions
- Helios Hospital Bad Saarow (DE)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
- Helios Klinikum Erfurt (DE)
Publication Details
- Journal
- Life
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3390/life16010169
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mike and Josie Harper Cancer Research Institute