Longitudinal biomarker trajectories and their prognostic utility for 21-day mortality in burn patients with sepsis: a retrospective cohort study
The dynamic patterns of multi-category biomarkers are strongly associated with short-term survival in burn sepsis. While burn severity is a dominant baseline risk factor, longitudinal trajectory analysis captures the essence of the host's recovery or failure, effectively stratifying patients into prognostically distinct subgroups. This trajectory-based phenotyping highlights the potential of monitoring the host response over time to improve risk assessment and guide personalized management.
Authors
- Na Huang (ORCID: https://orcid.org/0009-0007-2870-8042)
- Jiaqi Lou (ORCID: https://orcid.org/0000-0003-1316-7507)
- Guoying Jin
- Youfen Fan
- Xinyi Le
- Ziyi Xiang
- Xiaoyu Zhu
- Jiliang Li
- Sida Xu
- Shengyong Cui
Institutions
- Ningbo University (CN)
- University of Bonn (DE)
- Ningbo No. 2 Hospital (CN)
- Ningbo College of Health Sciences (CN)
- Ningbo No.6 Hospital (CN)
Publication Details
- Journal
- Inflammation Research
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1007/s00011-025-02178-2
- Primary Topic
- Burn Injury Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Ningbo
- Hwa Mei Hospital, University of Chinese Academy of Sciences
- Science and Technology Program of Zhejiang Province