Intra-articular Delivery of Recombinant Interleukin-1 Receptor Antagonist Protein (Anakinra) Enhances Graft Function in a Porcine Model of Osteochondral Repair
This study demonstrates that local provision of adjuvant anti-inflammatory therapeutics after OAT may enhance healing and protect graft integrity. This not only has implications for current clinical practice of osteochondral autograft (and allograft) procedures but also may allow expanded indications for advanced biological repair in a greater number of patients.
Authors
- Rachel A. Flaugh
- Kendall M. Masada (ORCID: https://orcid.org/0000-0001-5477-7892)
- Akbar N. Syed (ORCID: https://orcid.org/0009-0002-3270-7708)
- Bijan Dehghani (ORCID: https://orcid.org/0000-0002-3074-1454)
- Brendan D. Stoeckl (ORCID: https://orcid.org/0000-0002-1799-2312)
- Lorielle Laforest
- Elisabeth A. Lemmon (ORCID: https://orcid.org/0000-0002-3831-9629)
- Carla R. Scanzello (ORCID: https://orcid.org/0000-0002-9290-188X)
- Natalie L. Fogarty
- Austin C. Jenk (ORCID: https://orcid.org/0000-0003-3481-1234)
- David R. Steinberg
- E. Bernstein
- James L. Carey
- Robert L. Mauck
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- The American Journal of Sports Medicine
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1177/03635465251401225
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00