Overcoming Ceftaroline Resistance in MRSA Using Ceftaroline–Carbapenem Combination Therapy
The limited but rising threat of ceftaroline-resistant MRSA poses a therapeutic challenge. We show that ceftaroline plus carbapenems restores activity against a resistant strain both in vitro and in a murine bacteremia model. These findings support combination therapy as a potential strategy for difficult MRSA infections, warranting further clinical investigation.
Authors
- George Sakoulas (ORCID: https://orcid.org/0000-0002-6063-6217)
- Allen Jankeel (ORCID: https://orcid.org/0000-0003-1316-1332)
- Alaguvel Valliammai (ORCID: https://orcid.org/0000-0002-2578-1531)
- Erlinda R. Ulloa (ORCID: https://orcid.org/0000-0002-0330-278X)
- J. Olson
- Gabriel Pérez-Parra
- Anuj K Khetarpal
- Valeria Rodríguez-Guevara
- Vanessa Vu
Institutions
- Children's Hospital of Orange County (US)
- University of California, Irvine (US)
- Brown University (US)
- University of California San Diego (US)
- Sharp Rees-Stealy Medical Group (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1093/ofid/ofag009
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00