Elevated Plasma GDF-15 Levels Are Associated with Aging, Multimorbidity, and Tobacco Exposure in People with HIV
Elevated GDF-15 was consistently associated with multimorbidity in PWH, primarily driven by aging and tobacco smoking. GDF-15 appears to reflect a broader state of multisystem physiological stress than traditional endothelial activation markers, supporting its utility as a biomarker to identify PWH at higher risk of age-related comorbidities and to monitor the impact of modifiable risk factors in clinical care.
Authors
- Beatriz Calderón Cruz
- Antonio Ocampo
- Otilia Bisbal Pardo
- Eva Poveda
- Noemi Martínez López de Castro
- Inés Martínez Barros
- Victor Asensi
- Jorge Sanchez-Villegas
- CoRIS cohort
- Luis Enrique Morano
- Rafael Rodríguez-Rosado Martínez-Echevarrí
- Mayte Pérez-Olmeda
- Alexandre Pérez González
- Jacobo Alonso Domínguez
- Aida López López
Institutions
- Instituto de Salud Carlos III (ES)
- University Hospital Complex Of Vigo (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Hospital Universitario Virgen Macarena (ES)
- Galicia Sur Biomedical Foundation (ES)
- Hospital Universitario 12 De Octubre (ES)
- Centro Nacional de Microbiologia (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Servicio Gallego de Salud (ES)
- Medical Research Network (US)
- Instituto de Investigación Sanitaria del Principado de Asturias (ES)
Publication Details
- Journal
- Infectious Diseases and Therapy
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1007/s40121-026-01302-x
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00