Whole-genome DNA methylation analysis of Chinese hamster ovary cells undergoing media adaptation
These findings identify and characterize dynamic DNA methylation changes occurring during media adaptation and support their potential use as predictive indicators of CHO cell phenotypic changes in response to a dynamic culture environment. Furthermore, this work represents a valuable resource for the development of DNA methylation-based biomarkers for the optimization of CHO cell culture.
Authors
- Emeka I. Igwe
- Frank Lyko (ORCID: https://orcid.org/0000-0002-4873-5431)
- Jagdeep K. Sandhu (ORCID: https://orcid.org/0000-0002-0065-1335)
- Guo Xuan Wan
- Suki Roy
- Florian Böhl
- Lingzhi Huang
- Abraham Wong
Institutions
- German Cancer Research Center (DE)
- Evonik (Germany) (DE)
- DKFZ-ZMBH Alliance (DE)
- East Asia Research (SG)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fbioe.2026.1716758
- Primary Topic
- Viral Infectious Diseases and Gene Expression in Insects
- Type
- article
- Field-Weighted Citation Impact
- 0.00