The Berlin-Hannover ICANS severity assessment–a novel bedside test to evaluate CAR T-cell-associated neurotoxicity
BHISA may provide a more sensitive and more differentiated screening tool for ICANS than ICE by incorporating additional cognitive and motor domains, while remaining easy to use. This may enable earlier and more nuanced detection of CAR T related neurotoxicity, potentially improving patient monitoring across a heterogeneous population.
Authors
- Leonie Müller‐Jensen (ORCID: https://orcid.org/0000-0002-6388-9375)
- O. Penack
- Petra Huehnchen (ORCID: https://orcid.org/0000-0002-6825-7270)
- Sandra Nay (ORCID: https://orcid.org/0000-0002-4986-1181)
- Endres Matthias
- Christophe Peczynski (ORCID: https://orcid.org/0000-0002-3829-0088)
- Rebecca Ludwig (ORCID: https://orcid.org/0000-0002-6652-7935)
- Victoria Panagiota (ORCID: https://orcid.org/0000-0001-9715-6391)
- Lars Bullinger
- Franz Felix Konen (ORCID: https://orcid.org/0000-0002-8609-5674)
- Wolfgang Boehmerle (ORCID: https://orcid.org/0000-0001-7195-3894)
- Viktoria Gudi (ORCID: https://orcid.org/0000-0002-0438-2339)
- S. Carl
- Thiemo Malte Möllenkamp
- Christian Könecke
- Frederik Damm
- Lea Martha Grote-Levi
- Nora Möhn
- Konstantin F. Jendretzky
- Thomas Skripuletz
- Florian H. Heidel
- Eric Anil Buß
- Mareike Frick
- Lotta Völker
- Matthias Eder
Institutions
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- Medizinische Hochschule Hannover (DE)
- Humboldt-Universität zu Berlin (DE)
- University Hospital Münster (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fneur.2026.1726779
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Medizinischen Hochschule Hannover
- Berlin Institute of Health