Targeting the perimenopause window to delay ovarian ageing and enhance healthspan

Targeting the perimenopause window to delay ovarian ageing and enhance healthspan Adjunct Assistant Professor Zhongwei Huang and Dr. Paula Benny discuss perimenopause and ovarian ageing, highlighting the importance of future interventions focused on early detection, personalized treatments, and lifestyle modifications to improve health outcomes and longevity. Perimenopause is defined as the time preceding menopause, often lasting up to ten years (Cunningham et al, 2025). While menopause is more clearly identified with amenorrhea lasting for 12 continuous months, drastic hormonal shifts and symptoms such as hot flushes, perimenopause is less clearly recognized due to menstrual disturbances and a myriad of symptoms (e.g., vasomotor symptoms, sleep changes, etc) which make its clinical management and treatment challenging.