Associations Between Growth Differentiating Factor‐15 and Frailty in Older Adults From the MAPT Study
Elevated plasma GDF-15 levels were associated with frailty in older adults, suggesting its potential as a biomarker for increased vulnerability and an indicator of increased risk over time. Our results support a pleiotropic role of GDF-15, with low physiological levels not contributing to frailty development.
Authors
- Juan Luis Sánchez‐Sánchez (ORCID: https://orcid.org/0000-0002-2507-6015)
- B. Vellas
- A. Lucas
- Yves Rolland
Institutions
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Institut des Maladies Métaboliques et Cardiovasculaires (FR)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1002/jcsm.70182
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Les Laboratories Pierre Fabre
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Région Occitanie Pyrénées-Méditerranée
- Avid Radiopharmaceuticals
- European Regional Development Fund