NMR-based metabolomics in a clinical cohort: deciphering the metabolic characteristics of gout with the dampness-heat syndrome and elucidate the efficacy of Simiao Pill
This real-world clinical study systematically delineates the metabolic features of GDHS, innovatively linking TCM syndromes to specific metabolic disturbances. It confirms that SMP exerts its therapeutic effects through multi-targeted modulation of the metabolic network. This work provides a new scientific paradigm for the study of "disease-syndrome-treatment" in TCM.
Authors
- Yu Hu (ORCID: https://orcid.org/0000-0003-3898-0123)
- Xinya Zhang (ORCID: https://orcid.org/0000-0003-2485-8397)
- Maojie Wang (ORCID: https://orcid.org/0000-0003-1417-416X)
- Ying Han (ORCID: https://orcid.org/0000-0001-7958-4050)
- Guangli Yan
- Runyue HUANG
- Xijun Wang
- Chang Liu
- Le Yang
- Ye Sun
- Xueping Zhao
- Ling Kong
- Hui Sun
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1186/s13020-025-01289-6
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Key Research and Development Program of Heilongjiang
- National Natural Science Foundation of China