Distinct clinical and inflammatory signatures in anterior vs. posterior circulation strokes
Our findings establish that AC and PC strokes are not merely anatomical variants but distinct pathophysiological entities, each possessing a unique biological fingerprint. The discovery of opposing inflammatory profiles, coupled with the clear dissociation from standard clinical severity scores, provides a compelling rationale to move beyond a "one-size-fits-all" approach in stroke care. This evidence lays a critical foundation for developing subtype-specific diagnostic biomarkers and targeted immunomodulatory strategies, representing a key translational step toward advancing precision medicine for stroke patients.
Authors
- Einav Levy (ORCID: https://orcid.org/0000-0001-6278-8364)
- Galina Keigler
- Chen Hanna Ryder (ORCID: https://orcid.org/0000-0002-9028-1154)
- Carmit Gal (ORCID: https://orcid.org/0000-0002-2047-3345)
- Samih Badarny (ORCID: https://orcid.org/0000-0003-3305-6054)
- Gili Barkay
- Mohammad Naffaa
- Yori Gidron
- Dan Paz
- Michael Zagorodniuk
Institutions
- Bar-Ilan University (IL)
- Western Galilee College (IL)
- Western Galilee Hospital (IL)
- Istituto Nazionale di Fisica Nucleare, Galileo Galilei Institute for Theoretical Physics (IT)
- Center for Innovation (US)
- Tel Hai Academic College (IL)
- University of Haifa (IL)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fmed.2025.1613282
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00