Sex and gender differences in weight gain associated with second‐generation integrase strand transfer inhibitors: A scoping review
Second-generation INSTIs, especially dolutegravir, appear to be associated with greater average and excessive weight gain among cis women, although this effect varies by setting, regimen and clinical context. Further research, especially in diverse populations, is needed to explore underlying mechanisms, determine risk factors and evaluate these trends in newer antiretroviral medications.
Authors
- Elizabeth M. King (ORCID: https://orcid.org/0000-0003-3978-7624)
- Rowan Patterson
- Caitlin Chew (ORCID: https://orcid.org/0000-0003-0997-0137)
- Will Small (ORCID: https://orcid.org/0000-0001-6717-904X)
- Erin Kwak
- Undarmaa Enkhbat
- Tahani Shraida
Institutions
- University of British Columbia (CA)
- Simon Fraser University (CA)
- Mongolian National University (MN)
- Mongolian National University of Medical Sciences (MN)
- British Columbia Centre on Substance Use (CA)
- Children's & Women's Health Centre of British Columbia (CA)
- Women's Health Research Institute (CA)
- B.C. Women's Hospital & Health Centre (CA)
Publication Details
- Journal
- HIV Medicine
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1111/hiv.70190
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00