Analysis of the Feasibility of Concurrent Application of Magnetic Nanoparticles as MRI Contrast Agents and for Magnetic Hyperthermia

The aim of the article was to analyze the potential simultaneous use of magnetic nanoparticles as contrast agents in MRI imaging and for magnetic hyperthermia. The study proposed characterizing the nanoparticles using various measurement methods in order to investigate the relationships between different properties. The first stage involved measuring images of nanoparticle samples using scanning transmission electron microscopy (TEM) and dynamic light scattering (DLS). The diameter distribution of nanoparticles was determined based on image segmentation. The next step involved measuring relaxation properties of nanoparticles in low and high magnetic fields. The research was carried out for nanoparticle solutions of various concentrations and properties. The last step was measuring calorimetric properties of nanoparticles as a thermal source under alternating magnetic field excitation conditions. The range of nanoparticle diameters (20-25 nm) for which maximum losses occur in an alternating magnetic field corresponds to the diameter range in which the maximum r₂ relaxivity is observed.