Ring‐Opening Reaction of Benzoxazole Derivatives with Diazo Compounds Catalyzed by Fe(OTf) ₃

An efficient approach for the ring‐opening of benzoxazole derivatives involves utilizing diazo compounds in the presence of Fe(OTf) 3 as a catalyst. This method enables the efficient conversion of the oxazole ring into highly functionalized products that bear N ‐amino, amide, and hydroxy groups. This approach overcomes the strong steric hindrance of benzoxazole when it carries substituents at the C2 position. And it has the advantages of high yield, broad substrate scope, efficient atom utilization, and so on. Moreover, some of these compounds exhibit antibacterial activity, which offer a valuable reference for the future development of novel antimicrobial agents.