Increasing Access to Pediatric Allogeneic Hematopoietic Stem Cell Transplantation in South Africa

Current pediatric allogeneic hematopoietic stem cell transplantation (HSCT) services in South Africa do not meet the substantial demand in the country. The factors leading to this paucity are multifactorial, including a limited number of appropriate donors on our local registries, inadequate identification and referral of appropriate patients, long distances to travel to health facilities, socioeconomic inequality, and inadequate infrastructure and clinical expertise for the number of transplants required. We describe a model for a large HSCT unit that caters to insured and uninsured patients in order to ensure equitable access, and which is in line with the WHO health system building blocks. The scale at which transplantation will be achieved will allow for the development of local skills and expertise, which can be decentralized in the future to further improve HSCT access.

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Publication Details

Journal
Pediatric Blood & Cancer
Published
2026-01-21
DOI
https://doi.org/10.1002/1545-5017.70132
Primary Topic
Hematopoietic Stem Cell Transplantation
Type
article
Field-Weighted Citation Impact
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Increasing Access to Pediatric Allogeneic Hematopoietic Stem Cell Transplantation in South Africa

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Increasing Access to Pediatric Allogeneic Hematopoietic Stem Cell Transplantation in South Africa

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article en

Abstract

Current pediatric allogeneic hematopoietic stem cell transplantation (HSCT) services in South Africa do not meet the substantial demand in the country. The factors leading to this paucity are multifactorial, including a limited number of appropriate donors on our local registries, inadequate identification and referral of appropriate patients, long distances to travel to health facilities, socioeconomic inequality, and inadequate infrastructure and clinical expertise for the number of transplants required. We describe a model for a large HSCT unit that caters to insured and uninsured patients in order to ensure equitable access, and which is in line with the WHO health system building blocks. The scale at which transplantation will be achieved will allow for the development of local skills and expertise, which can be decentralized in the future to further improve HSCT access.

Pediatric Blood & CancerVol. 73(4)
University of Cape Town (ZA), Chris Hani Baragwanath Hospital (ZA), Groote Schuur Hospital (ZA), Steve Biko Hospital (ZA), Wits University Donald Gordon Medical Centre (ZA), Research ICT Africa (ZA), German National Bone Marrow Donor Registry (DE), Netcare Unitas Hospital (ZA), Red Cross War Memorial Children's Hospital (ZA), University of Pretoria (ZA)
Industry, innovation and infrastructure
Openalex Percentile: Top 84%
Hematopoietic Stem Cell Transplantation
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