A Case Report: Effects of a ketogenic diet on PTEN mutation-associated autism spectrum disorder
This study provides preliminary clinical evidence for KD in PTEN-related ASD, suggesting potential modulation of the PI3K/AKT/mTOR pathway and neuroinflammation. Although limited by its single-case design and short duration, it offers a novel therapeutic approach for PTEN-mutant ASD. Multicenter randomized controlled trials are warranted to validate efficacy and safety.
Authors
- Jingjing Gao (ORCID: https://orcid.org/0000-0002-0791-4951)
- Yanze Wang
- Aihua Cao
- Zhiyue Liu
- Zihan Yan
- Yongheng Zhao
- Linlin Zhang
- Lihong Wang
- Yanshuo Guo
- Mengna Zhu
Institutions
- Qilu Hospital of Shandong University (CN)
- Dezhou University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fnut.2026.1721018
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00