Genomic Characterization of <i>Klebsiella pneumoniae</i> Causing Invasive Disease in South African Infants: Observational Studies Between 2018 and 2023
Although a wide diversity of strains were associated with Kpn invasive disease, over 80% of the cases were attributed to 11 K loci. These data provide critical insights into KPn epidemiology and highlight potential antigen targets for vaccine development in young African children.
Authors
- Gaurav Kwatra (ORCID: https://orcid.org/0009-0008-2032-1975)
- Nicholas John Dean (ORCID: https://orcid.org/0000-0001-9995-0687)
- Anika M. van Niekerk (ORCID: https://orcid.org/0009-0006-0091-2810)
- Niree Naidoo (ORCID: https://orcid.org/0000-0003-3912-8258)
- Sana Mahtab (ORCID: https://orcid.org/0000-0002-2606-6951)
- Vicky L. Baillie (ORCID: https://orcid.org/0000-0003-1327-9090)
- Raphael Simon (ORCID: https://orcid.org/0000-0002-4136-0948)
- Lubomira Andrew
- Shama Khan (ORCID: https://orcid.org/0000-0002-0874-5029)
- Yogandree Ramsamy (ORCID: https://orcid.org/0000-0001-7112-8392)
- Sithembiso Velaphi (ORCID: https://orcid.org/0000-0002-9219-8485)
- Urvi Rajyaguru
- Kimberleigh Storath
- Madhi Sa
- Prof Ziyaad Dangor
- Firdose L Nakwa
- Lara Van der Merwe
- Courtney P Olwagen
- Alane Izu
- Imaan Dunn
- Mohamed Said
- Carmen Briner
- Robert G K Donald
- Stephanie Jones
- Renate Strehlau
Institutions
- National Health Laboratory Service (ZA)
- South African Medical Research Council (ZA)
- Cincinnati Children's Hospital Medical Center (US)
- Tshwane University of Technology (ZA)
- University of Cape Town (ZA)
- Christian Medical College, Vellore (IN)
- Pfizer (United States) (US)
- University of the Witwatersrand (ZA)
- Chris Hani Baragwanath Hospital (ZA)
- University of Pretoria (ZA)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1093/ofid/ofag004
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00