Engineered CGRP Eye Drops Restore Tear Secretion via TRPM8-SSN Circuitry in a Postrefractive Surgery Mouse Model
Our data demonstrate that CGRP expression in the cornea is downregulated in postrefractive surgery dry eye through decreasing TRPM8-SSN activity. eCGRP may provide an effective therapeutic approach for its prevention and treatment.
Authors
- Xiaoyu Li (ORCID: https://orcid.org/0009-0002-3652-620X)
- M. Liu
- Mengyao Zhang (ORCID: https://orcid.org/0000-0002-3932-3160)
- Mingli Qu
- Qingjun Zhou
- Yali Fu
- Xiaofei Bai
- Shengqian Dou
- Qun Wang
Institutions
- Shandong Eye Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1167/iovs.67.1.45
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00