Minocycline alleviates mechanical allodynia and modulates hippocampal neuroinflammatory markers in a rat model of neuropathic pain induced by spinal nerve transection
Minocycline administration significantly mitigates mechanical allodynia and modulates hippocampal neuroinflammatory markers in a rat model of neuropathic pain. These results highlight minocycline's potential as a therapeutic option for neuropathic pain, particularly in targeting neuroinflammation within the hippocampus.
Authors
- Runli Tian
- Qinghua Li (ORCID: https://orcid.org/0000-0002-4547-8513)
- Renfeng Du
- YongNan Li
- Dandan He
- Qingling Luo
- Zhaohui Guo
Institutions
- Aviation Industry Corporation of China (China) (CN)
- Harbin Medical University (CN)
- ShenZhen People’s Hospital (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Pudong Medical Center (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- Beijing YouAn Hospital (CN)
Publication Details
- Journal
- Neuroreport
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1097/wnr.0000000000002221
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00