Neutrophil-derived exosomes inhibit gastric cancer progression via miR-101-3p-mediated suppression of MCL1
We demonstrate that N-Exo exerts tumor-suppressive effects by delivering miR-101-3p, which dually targets and suppresses MCL1 expression. Moreover, rmIL-36γ treatment enhances both miR-101-3p abundance and anti-tumor efficacy in neutrophils. These findings highlight the N-Exo/miR-101-3p/MCL1 axis as a therapeutic target and support cytokine priming as a strategy to enhance neutrophil-based cancer therapy.
Authors
- S Wang
- Boyue Fan
- Xinjian Fang
- Jiayi Wang (ORCID: https://orcid.org/0009-0006-5567-8419)
- Junxiong Wang (ORCID: https://orcid.org/0000-0001-6998-0711)
- Shuting Meng (ORCID: https://orcid.org/0000-0003-0679-0878)
- Yuzhu Wang (ORCID: https://orcid.org/0009-0009-3416-316X)
- Qian Yu (ORCID: https://orcid.org/0000-0002-9572-4188)
- Jiahui Zhang
- Jiayuan Shi
- Xiaotong Dong
- Xiaoxin Zhang
- Xu Zhang
- Min Fu
- Runbi Ji
Institutions
- Jiangsu University (CN)
- Gaochun People's Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1186/s12935-026-04173-x
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 22.24